BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Claremont Center for the Mathematical Sciences - ECPv6.15.17.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Claremont Center for the Mathematical Sciences
X-ORIGINAL-URL:https://colleges.claremont.edu/ccms
X-WR-CALDESC:Events for Claremont Center for the Mathematical Sciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20190310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20191103T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20200308T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20201101T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20200127T161500
DTEND;TZID=America/Los_Angeles:20200127T171500
DTSTAMP:20260416T030143
CREATED:20191021T210941Z
LAST-MODIFIED:20200120T080056Z
UID:1616-1580141700-1580145300@colleges.claremont.edu
SUMMARY:Applied Math Talk:  Statistical Mechanics of Molecular Evolution and its Role in the SELEX Protocol given by Prof. Bhaven Mistry (CMC)
DESCRIPTION:Antibodies are the standard biomolecule for marking molecular structures and delivering drugs due to their specific binding capabilities. However\, they are expensive to produce and their relatively large size prevents their easy traversal of bi-lipid membranes. Over the past 30 years\, molecular recognition has also been achieved through the use of aptamers\, short oligonucleotide sequences that fold in conformations that allow them to specifically bind to targets. These aptamers are produced rapidly and efficiently through a process known as Systematic Evolution of Ligands by EXponential enrichment (SELEX) whereby a molecular selection mechanism based on competitive binding enriches the population of given strands and removes unwanted sequences\, yielding high target specificity and affinity. Current SELEX mathematical models are formulated in the mass action limit\, which assumes large aptamer/target concentrations. Low number effects\, such as the extinction probability of the best binding aptamer\, however\, require a full stochastic model currently lacking in the literature. We derive such a statistical mechanics model verifying that in the large aptamer/target concentration limit\, the mass action results are recovered. Our stochastic model also allows us to calculate the extinction probability and efficiency of selection\, and to propose a method of optimizing the SELEX protocol.
URL:https://colleges.claremont.edu/ccms/event/applied-math-talk-given-by-prof-bhaven-mistry-cmc/
LOCATION:Emmy Noether Room\, Millikan 1021\, Pomona College\, 610 N. College Ave.\, Claremont\, California\, 91711
CATEGORIES:Applied Math Seminar
GEO:34.099908;-117.7142522
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Emmy Noether Room Millikan 1021 Pomona College 610 N. College Ave. Claremont California 91711;X-APPLE-RADIUS=500;X-TITLE=610 N. College Ave.:geo:-117.7142522,34.099908
END:VEVENT
END:VCALENDAR