BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Claremont Center for the Mathematical Sciences - ECPv6.15.17.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Claremont Center for the Mathematical Sciences
X-ORIGINAL-URL:https://colleges.claremont.edu/ccms
X-WR-CALDESC:Events for Claremont Center for the Mathematical Sciences
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20200308T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20201101T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20211011T161500
DTEND;TZID=America/Los_Angeles:20211011T171500
DTSTAMP:20260519T085013
CREATED:20210922T024054Z
LAST-MODIFIED:20211011T071415Z
UID:2387-1633968900-1633972500@colleges.claremont.edu
SUMMARY:Applied Math Seminar -- Leif Zinn-Brooks (HMC/Scripps)
DESCRIPTION:Title: Circadian Rhythms in Multinucleate Cells \nAbstract: \nCircadian rhythms are among the most researched cellular processes\, but limited work has been done on how these rhythms are coordinated between nuclei in multinucleate cells. I’ll analyze a mathematical model for circadian oscillations in a multinucleate cell\, motivated by mRNA and protein data from the filamentous fungus Neurospora crassa. Stochastic simulations of this model illuminate the importance of mRNA-protein phase separation\, in which mRNAs are kept close to the nucleus in which they were transcribed\, while proteins can diffuse freely across the cell. This phase separation allows for a robust oscillator to be assembled with very low mRNA counts. I’ll also discuss how the labor of transcribing mRNAs is divided between nuclei\, both when nuclei are evenly spaced across the cell and when they are not. Division of this labor can be regulated by controlling the amount of cytoplasmic volume available to each nucleus. Our results indicate that there is potential for emergent organization and extreme mRNA efficiency in multinucleate cells.
URL:https://colleges.claremont.edu/ccms/event/applied-math-seminar-leif-zinn-brooks-hmc-scripps/
LOCATION:Emmy Noether Room\, Estella 1021\, Pomona College\,\, 610 N. College Ave.\, Claremont\, CA\, 91711\, United States
CATEGORIES:Applied Math Seminar
ORGANIZER;CN="Heather Zinn Brooks":MAILTO:hzinnbrooks@g.hmc.edu
END:VEVENT
END:VCALENDAR