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DTSTART;TZID=America/Los_Angeles:20221031T161500
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SUMMARY:Applied Math Seminar: Anna Nelson (Duke)
DESCRIPTION:Title: Mathematical modeling of polymerization processes in physiology\n\nAbstract: Polymerization\, or aggregation\, is essential for many physiological systems. For example\, the emergence of a fibrin polymer mesh during the formation of a blood clot is required for a stable clot and long-term\, sustained intracellular transport in neurons rely on persistent yet dynamic polymers that comprise the microtubule cytoskeleton. In the first part of the talk\, I will discuss a kinetic polymerization model that represents the formation of a fibrin polymer mesh with interactions with its precursor molecule\, fibrinogen. With this model\, we investigate how fibrin-fibrinogen interactions can impact gel structure (such as concentration of branch points) and gel time. In the second part\, I will introduce a stochastic mathematical model of individual microtubule growth and catastrophe in the dendrite of a neuron. Using parameters informed by experimental data\, we explore what mechanisms could control the equilibrium microtubule length and validate these mechanisms using fluorescence microscopy data.  \n\n 
URL:https://colleges.claremont.edu/ccms/event/applied-math-seminar-anna-nelson-duke/
LOCATION:Shanahan 2407 at Harvey Mudd College\, Claremont\, CA\, 91711\, United States
CATEGORIES:Applied Math Seminar
ORGANIZER;CN="Heather Zinn Brooks":MAILTO:hzinnbrooks@g.hmc.edu
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