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DTSTART;TZID=America/Los_Angeles:20230403T161500
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DTSTAMP:20260519T233800
CREATED:20221020T204917Z
LAST-MODIFIED:20230320T152627Z
UID:2965-1680538500-1680542100@colleges.claremont.edu
SUMMARY:Applied Math Seminar: Ivy Xiong (USC)
DESCRIPTION:Title: A common pathway to cancer: oncogenic mutations abolish p53 oscillations. \nAbstract:\nThe tumor suppressor p53 oscillates in response to DNA double-strand breaks\, a behavior that has been suggested to be essential to its anti-cancer function. Nearly all human cancers have genetic alterations in the p53 pathway; a number of these alterations have been shown to be oncogenic by experiment. These alterations include somatic mutations and copy number variations as well as germline polymorphisms. Intriguingly\, they exhibit a mixed pattern of interactions in tumors\, such as co-occurrence\, mutual exclusivity\, and paradoxically\, mutual antagonism. Using a differential equation model of p53-Mdm2 dynamics\, I employ Hopf bifurcation analysis to show that these alterations have a common mode of action\, to abolish the oscillatory competence of p53\, thereby impairing its tumor suppressive function. In this analysis\, diverse genetic alterations\, widely associated with human cancers clinically\, have a unified mechanistic explanation of their role in oncogenesis. In this talk\, I will also discuss the role of physiological oscillations in health and disease broadly. \nReferences: \nXiong\, L.\, and Garfinkel\, A. (2022). A common pathway to cancer: Oncogenic mutations abolish p53 oscillations. Progress in Biophysics and Molecular Biology. DOI: 10.1016/j.pbiomolbio.2022.06.002 \nXiong\, L.\, and Garfinkel\, A. (2023). Are physiological oscillations “physiological”? arXiv. DOI: 10.48550/arXiv.2301.08996
URL:https://colleges.claremont.edu/ccms/event/applied-math-seminar-ivy-xiong-usc/
LOCATION:Claremont\, CA\, 91711\, United States
CATEGORIES:Applied Math Seminar
ORGANIZER;CN="Heather Zinn Brooks":MAILTO:hzinnbrooks@g.hmc.edu
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