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DTSTART;TZID=America/Los_Angeles:20230403T161500
DTEND;TZID=America/Los_Angeles:20230403T171500
DTSTAMP:20260508T023425
CREATED:20221020T204917Z
LAST-MODIFIED:20230320T152627Z
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SUMMARY:Applied Math Seminar: Ivy Xiong (USC)
DESCRIPTION:Title: A common pathway to cancer: oncogenic mutations abolish p53 oscillations. \nAbstract:\nThe tumor suppressor p53 oscillates in response to DNA double-strand breaks\, a behavior that has been suggested to be essential to its anti-cancer function. Nearly all human cancers have genetic alterations in the p53 pathway; a number of these alterations have been shown to be oncogenic by experiment. These alterations include somatic mutations and copy number variations as well as germline polymorphisms. Intriguingly\, they exhibit a mixed pattern of interactions in tumors\, such as co-occurrence\, mutual exclusivity\, and paradoxically\, mutual antagonism. Using a differential equation model of p53-Mdm2 dynamics\, I employ Hopf bifurcation analysis to show that these alterations have a common mode of action\, to abolish the oscillatory competence of p53\, thereby impairing its tumor suppressive function. In this analysis\, diverse genetic alterations\, widely associated with human cancers clinically\, have a unified mechanistic explanation of their role in oncogenesis. In this talk\, I will also discuss the role of physiological oscillations in health and disease broadly. \nReferences: \nXiong\, L.\, and Garfinkel\, A. (2022). A common pathway to cancer: Oncogenic mutations abolish p53 oscillations. Progress in Biophysics and Molecular Biology. DOI: 10.1016/j.pbiomolbio.2022.06.002 \nXiong\, L.\, and Garfinkel\, A. (2023). Are physiological oscillations “physiological”? arXiv. DOI: 10.48550/arXiv.2301.08996
URL:https://colleges.claremont.edu/ccms/event/applied-math-seminar-ivy-xiong-usc/
LOCATION:Claremont\, CA\, 91711\, United States
CATEGORIES:Applied Math Seminar
ORGANIZER;CN="Heather Zinn Brooks":MAILTO:hzinnbrooks@g.hmc.edu
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DTSTART;TZID=America/Los_Angeles:20230404T121500
DTEND;TZID=America/Los_Angeles:20230404T131000
DTSTAMP:20260508T023425
CREATED:20230112T225942Z
LAST-MODIFIED:20230327T230516Z
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SUMMARY:Noise stability of ranked choice voting (Steven Heilman\, USC)
DESCRIPTION:Given votes for candidates\, what is the best way to determine the winner of the election\, if some of the votes have been corrupted or miscounted?  As we saw in Florida in 2000\, where a difference of 537 votes determined the president of the United States\, the electoral college system does not seem to be the best voting method. We will survey some recent progress on the above question along with some open problems. In particular\, we consider which ranked choice voting method is most stable to corrupted or miscounted votes. \nhttps://arxiv.org/abs/2209.11183
URL:https://colleges.claremont.edu/ccms/event/antc-talk-steven-heilman-usc/
LOCATION:Davidson Lecture Hall\, CMC\, 340 E 9th St\, Claremont\, CA\, 91711\, United States
CATEGORIES:Algebra / Number Theory / Combinatorics Seminar
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DTSTART;TZID=America/Los_Angeles:20230405T161500
DTEND;TZID=America/Los_Angeles:20230405T173000
DTSTAMP:20260508T023425
CREATED:20230122T184214Z
LAST-MODIFIED:20230403T235658Z
UID:3045-1680711300-1680715800@colleges.claremont.edu
SUMMARY:Wallis and Landen: A Tale of two integrals (Prof. Victor Moll\, Tulane University)
DESCRIPTION:Title: Wallis and Landen: A Tale of two integrals \nSpeaker: Victor Moll\, Department of Mathematics\, Tulane University \nAbstract: Victor Moll Abstract \n  \n\n\n\n\n\nI was born in Santiago\, Chile during the last millenium\, on October 31st. My father was a doctor in a small town. I must have been bothering my family\, so they put me to school at an early age. My first mathematical mentor was Maria Pardo\, who recognized that I had some talent for Mathematics. Since this came easy\, I spent most of my middle and high school years trying to learn some more. The other subjects suffered.\nAfter high-school\, liking Mathematics\, I enrolled in an Engineering School. Not a good idea. But since one could transfer to study Mathematics\, everything worked out fine. After graduation\, since PhD’s in Math were rare in Chile\, I was hired as a faculty member of Universidad Santa Maria (not a catholic school\, this is the last name of some rich chilean person). In 1980 I left for New York City\, to begin my graduate education at the Courant Institute of NYU. I was interested in Number Theory and this is one of the best places for Applied Mathematics. Talk about being clueless. There I met my wife\, Lisa Fauci\, then also a student. (She is the former president of SIAM and has a large collections of well-deserved awards). We both got positions at Tulane University in 1986. We figure we will try New Orleans for a year or two. Never left.\nMy PhD thesis was in the stability of waves for a model for nerve conduction. Did that until I got tenure. After tenure I spent a sabbatical to finish writing a book on Elliptic Curves (jointly with my advisor\, Henry McKean). Then a piece of luck: a first year graduate student (George Boros) told me that he could compute an integral. Not impressed\, I tried Mathematica and it was unable to find the answer. This changed my research area. I have been computing integrals since then. Have written a variety of papers on this and three books (at diverse levels). I am currently the scientific editor of the table by Gradshteyn and Ryzhik\, one of the most used tables in the world.\nI enjoy working with undergraduate and graduate students\, professional colleagues and amateurs. I have been part of REU programs such as SIMU (in Puerto Rico)\, MSRI-UP (at Berkeley) and a variety of summer programs at Tulane. Lately I have been participating in programs aimed at faculty coming from institutions with high teaching load (Park City\, Utah and ICERM\, at Brown). My latest projects involves a new method called ”The method of brackets”\, invented by my collaborator Ivan Gonzalez\, a professor of Physics in Valparaiso\, Chile. Our works deals with the evaluation of Feynman diagrams\, coming in the description of elementary particles. To me\, this is the last leg of a cycle. As a high school student\, I wanted to study Particle Physics. It is never too late to go back to the beginning.
URL:https://colleges.claremont.edu/ccms/event/prof-victor-moll/
LOCATION:Argue Auditorium\, Pomona College\, 610 N. College Ave.\, Claremont\, CA\, 91711\, United States
CATEGORIES:Colloquium
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DTSTART;TZID=America/Los_Angeles:20230406T163000
DTEND;TZID=America/Los_Angeles:20230406T173000
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SUMMARY:Radial solutions to semilinear elliptic partial differential equations (Professor Alfonso Castro\, HMC)
DESCRIPTION:Using elementary methods from differential equations and analysis we will consider the existence and multiplicity of solutions to semilinear partial differential equations with boundary conditions.
URL:https://colleges.claremont.edu/ccms/event/radial-solutions-to-semilinear-elliptic-partial-differential-equationsprofessor-alfonso-castro-hmc/
LOCATION:Roberts North 105\, CMC\, 320 E. 9th St.\, Claremont\, CA\, 91711\, United States
CATEGORIES:Analysis Seminar
ORGANIZER;CN="Asuman Aksoy":MAILTO:asuman.aksoy@claremontmckenna.edu
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