{"id":2965,"date":"2022-10-20T13:49:17","date_gmt":"2022-10-20T20:49:17","guid":{"rendered":"https:\/\/colleges.claremont.edu\/ccms\/?post_type=tribe_events&#038;p=2965"},"modified":"2023-03-20T08:26:27","modified_gmt":"2023-03-20T15:26:27","slug":"applied-math-seminar-ivy-xiong-usc","status":"publish","type":"tribe_events","link":"https:\/\/colleges.claremont.edu\/ccms\/event\/applied-math-seminar-ivy-xiong-usc\/","title":{"rendered":"Applied Math Seminar: Ivy Xiong (USC)"},"content":{"rendered":"<p style=\"font-weight: 400;\"><strong>Title:<\/strong>\u00a0A common pathway to cancer: oncogenic mutations abolish p53 oscillations.<\/p>\n<p style=\"font-weight: 400;\"><strong>Abstract<\/strong>:<br \/>\nThe tumor suppressor p53 oscillates in response to DNA double-strand breaks, a behavior that has been suggested to be essential to its anti-cancer function. Nearly all human cancers have genetic alterations in the p53 pathway; a number of these alterations have been shown to be oncogenic by experiment. These alterations include somatic mutations and copy number variations as well as germline polymorphisms. Intriguingly, they exhibit a mixed pattern of interactions in tumors, such as co-occurrence, mutual exclusivity, and paradoxically, mutual antagonism. Using a differential equation model of p53-Mdm2 dynamics, I employ Hopf bifurcation analysis to show that these alterations have a common mode of action, to abolish the oscillatory competence of p53, thereby impairing its tumor suppressive function. In this analysis, diverse genetic alterations, widely associated with human cancers clinically, have a unified mechanistic explanation of their role in oncogenesis. In this talk, I will also discuss the role of physiological oscillations in health and disease broadly.<\/p>\n<p style=\"font-weight: 400;\"><strong>References:<\/strong><\/p>\n<p style=\"font-weight: 400;\">Xiong, L., and Garfinkel, A. (2022). A common pathway to cancer: Oncogenic mutations abolish p53 oscillations.\u00a0<em>Progress in Biophysics and Molecular Biology<\/em>. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.pbiomolbio.2022.06.002\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/doi.org\/10.1016\/j.pbiomolbio.2022.06.002&amp;source=gmail&amp;ust=1675202044162000&amp;usg=AOvVaw2kEtUCHWJSssgWNmWGxvEM\">10.1016\/j.pbiomolbio.2022.06.002<\/a><\/p>\n<p style=\"font-weight: 400;\">Xiong, L., and Garfinkel, A. (2023). Are physiological oscillations \u201cphysiological\u201d?\u00a0<em>arXiv<\/em>. DOI:\u00a0<a href=\"https:\/\/arxiv.org\/abs\/2301.08996\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/arxiv.org\/abs\/2301.08996&amp;source=gmail&amp;ust=1675202044162000&amp;usg=AOvVaw2YD12yzKa-wXIkifj_tYN3\">10.48550\/arXiv.2301.08996<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:\u00a0A common pathway to cancer: oncogenic mutations abolish p53 oscillations. Abstract: The tumor suppressor p53 oscillates in response to DNA double-strand breaks, a behavior that has been suggested to be [&hellip;]<\/p>\n","protected":false},"author":170,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_tec_slr_enabled":"","_tec_slr_layout":""},"tags":[],"tribe_events_cat":[15],"class_list":["post-2965","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-applied-math-seminar","cat_applied-math-seminar"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Applied Math Seminar: Ivy Xiong (USC) - Claremont Center for the Mathematical Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/colleges.claremont.edu\/ccms\/?post_type=tribe_events&p=2965\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Applied Math Seminar: Ivy Xiong (USC) - Claremont Center for the Mathematical Sciences\" \/>\n<meta property=\"og:description\" content=\"Title:\u00a0A common pathway to cancer: oncogenic mutations abolish p53 oscillations. 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