Growth regulation and pattern formation are two main problems in developmental biol-
\nogy. How cells know when to stop growing at certain tissue size with specic shape is an important
\nquestion in both developmental biology and regenerative medicine, and it is still an unsolved mystery
\nin many systems. During the growth, tissues and organs always exhibit self-government to some
\nextent. Cells stop proliferation precisely when the intended size of the tissue or organ is achieved.
\nMeanwhile, dierential cell shapes in space are integrated to give rise to well-organized overall struc-
\nture. Uncontrolled growth of the cells in tissues or organs will lead to abnormal development or
\nfatal diseases such as cancer. Therefore, developing an extensible predictive mathematical model
\nfor exploring the mechanisms involved in the tissue development is signicant for understanding
\nthe fundamental principles in developmental biology, with a broad range of applications from tissue
\nengineering to biomanufacturing and biotech industry. Experimental data suggests that mechanical
\nproperties of cells and chemical signals in both intracellular and extracellular domains play critical
\nroles in size control and shape formation. Here we develop a multiscale, mechochemical coupled
\nmodel of tissue growth control. This rst-of-class modeling approach provides sub-cellular details
\nto both mechanical properties and chemical signaling during tissue growth. This model is applied
\nto test competing hypotheses in the eld to resolve the highly debated question of how tissues reach
\ntheir nal size, as well as how the tissue shape is determined simultaneously.<\/p>\n","protected":false},"excerpt":{"rendered":"
Growth regulation and pattern formation are two main problems in developmental biol- ogy. How cells know when to stop growing at certain tissue size with specic shape is an important […]<\/p>\n","protected":false},"author":79,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_tec_slr_enabled":"","_tec_slr_layout":""},"tags":[],"tribe_events_cat":[12],"class_list":["post-849","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-colloquium","cat_colloquium"],"acf":[],"yoast_head":"\n