Modeling drug release for in vitro experiments (Minaya Villasana De Armas, Universidad Simon Bolivar)

Abstract: It is common to use adjuvants in immunotherapeutic regimens to strengthen the immune response. However, multiple dosages are required making it inconvenient for the patient. Hydrogels have been proposed as a vehicle to administer adjuvant and antigen in a sustained slow release thus reducing the need for re-administration.

In this instance, we use experimental data for stability studies on two different thermosensitive pentablock hydrogels as well as release of three adjuvants suspended in the hydrogels or in PLGA nanoparticles. The goal is to model this release and provide a framework by which these models can describe the various release profiles efficiently.